Unidox Solutab: instructions for use. What does Unidox Solutab help with? Instructions for use Unidox Solutab instructions for use why

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Tradename

Unidox Solutab (Unidox Solutab).

International Nonproprietary Name (INN)

Doxycycline.

Pharmacological group

Unidox Solutab belongs to the group antibiotics tetracycline series.

Compound

One Unidox tablet contains doxycycline monohydrate in an amount equal to 100 mg of pure doxycycline - this is the active substance of Unidox Solutab tablets. Excipients:

• hyprolose (low-substituted);
• magnesium stearate;
• microcrystalline cellulose;
• hypromellose;
• lactose monohydrate;
• colloidal silicon dioxide (anhydrous).

The tablets are packaged in plastic blisters of 10 pieces, one in a cardboard box.

Release form

The drug Unidox Solutab is available in the form of dispersible (soluble) biconvex round tablets. The color can be different shades of yellow. A notch is visible on one side of the tablet, and “173” is engraved on the other.

pharmachologic effect

Doxycycline, which is part of Unidox, is a substance that stops the proliferation of bacterial cells, which is associated with a violation of protein formation in the cells of microorganisms.

This drug belongs to the group of broad-spectrum antibiotics, but it should be noted that many microorganisms have currently become insensitive to this antibiotic.

In our time, the most sensitive to Unidox among gram-positive cocci are pneumococcus, most enterococci and some groups of staphylococci, and among gram-negative cocci - moraxella and meningococcus. Most gonococci are insensitive.

Doxycycline is active against leptospira, rickettsia, spirochetes, chlamydia, borrelia, mycoplasma, some protozoa and actinomycetes.

The destructive effect of doxycycline has been established against certain types of gram-positive and gram-negative bacilli: yersinia, listeria, brucella, vibrios (including cholera), pathogens of plague, granuloma inguinale, tularemia, anthrax.

Salmonella, Enterobacter, Escherichia coli, Klebsiella, Shigella are resistant to doxycycline.

Among anaerobic microorganisms, fusobacteria, clostridia, and propionibacteria (P. acnes) are susceptible to the action of doxycycline.

Pharmacokinetics

When taken orally, it is perfectly absorbed, and its absorption and effect in the body does not depend on food intake. In the period from an hour to 3 hours after taking the drug, the maximum concentration of doxycycline is recorded in the blood. This drug also creates a fairly high concentration of doxycycline in the tissues. In the cerebrospinal fluid, the level of the drug is 25% higher than in the blood, in bile – 20%. The drug is able to cross the placenta to the fetus and enter breast milk. It is eliminated from the body through the gastrointestinal tract. The period during which exactly half the dose of the drug taken is eliminated from the body is 20 hours.

Application

The drug Unidox Solutab has found wide use in the treatment of diseases such as:

• STIs (sexually transmitted infections) – gonorrhea, syphilis, lymphogranuloma venereum, granuloma inguinale;
• chlamydial infections - trachoma, urethritis, cervicitis, psittacosis, prostatitis;
• mycoplasma infections;
• rosacea (rosacea);
• acne;
• borreliosis – relapsing fever, Lyme disease;
• bacterial zoonotic infections – tularemia, plague, brucellosis, anthrax, leptospirosis;
• rickettsiosis;
• lower respiratory tract infections - community-acquired atypical pneumonia, chronic bronchitis in the acute stage;
• gynecological infectious diseases - salpingoophoritis, adnexitis, endometritis;
• actinomycosis;
• acute dacryocystitis;
• intestinal infectious diseases – yersiniosis, cholera;
• animal bites complicated by wound infection;
• cat scratch disease;
• prevention of tropical malaria.

Contraindications

• children under 8 years of age;
• severe liver pathology;
• pregnancy;
• lactation period.

Instructions for use

Pimples (acne, acne vulgaris, rosacea)
In case of intolerance and ineffectiveness of local treatment of acne, in case of severe and moderate course of the disease (including scar formation), systemic antibiotic therapy is prescribed. In this case, the antibiotic Unidox is the drug of choice. Take 100-200 mg of the drug, dividing the dose into 2 doses. The duration of treatment is 12 days.
Ureaplasmosis
Treatment of ureaplasmosis is carried out by taking 100 mg of the drug Unidox twice a day with a 12-hour break, for 7 days.

Chlamydia
For the treatment of urogenital chlamydia, Unidox is taken 100 mg twice a day for a week.

Prostatitis
The duration of treatment of bacterial prostatitis with Unidox at a daily dose of 200 mg is at least 4 weeks. The drug is taken in two doses, 12 hours apart.

Syphilis
In case of intolerance to penicillin antibiotics, reserve antibiotics are used in the treatment of syphilis, one of which is Unidox Solutab. For preventive treatment, the drug is prescribed 3 times a day, 100 mg, for 2 weeks. For the treatment of fresh forms, the period of use of the drug at the same dose is increased to 20-25 days.

Gonorrhea
Uncomplicated subacute and acute forms of gonorrhea can be treated with Unidox Solutab. Tablets are taken orally at 100 mg (the first dose is 200 mg) every 12 hours, the total dose of treatment is 1000 mg. For other forms of gonorrhea, treatment is carried out according to the same scheme, but the total dose per course is 1500 mg.

Granuloma
For the treatment of lymphogranuloma venereum and inguinal granuloma (donovanosis), Unidox tablets are taken for 3 weeks, 100 mg every 12 hours.

Actinomycosis
Actinomycosis can be treated with Unidox in a daily dose of 0.2 g, taken for six months to a year.

Eye diseases
Eye diseases, such as trachoma and acute dacryocystitis, are treated with Unidox for 21-28 days at a daily dose of 200 mg, in two doses.
Cholera
For cholera, 300 mg of Unidox is prescribed once.

Rickettsial disease
The treatment regimen for rickettsiosis includes prescribing Unidox 100 mg twice a day for a week (or for 2 days after normalization of body temperature).

Zoonosis
The treatment regimen for bacterial zoonoses is similar, the only differences are in the duration of drug administration. Unidox is prescribed 100 mg every 12 hours, for plague - 10 days, for tularemia - 2 weeks, for anthrax - 2 months.

Brucellosis
The treatment regimen for brucellosis also includes the administration of Unidox 100 mg twice a day, in combination with other antimicrobial drugs (streptomycin, rifampicin).

Leptospirosis
To prevent leptospirosis, take 100 mg of Unidox once a week.
For tick-borne borreliosis, take 0.1 g of the drug every 12 hours for a month. For prevention purposes, 200 mg of Unidox is prescribed once.

Malaria
When traveling to areas where malaria is endemic, you must take Unidox the day before departure, and take the drug during the entire period of your stay in this country. The total interval for taking Unidox should not exceed 6 months. The daily dose is 100 mg.
Respiratory system infections
For lower respiratory tract infections, the duration of Unidox therapy is from 7 to 10 days, for mycoplasma pneumonia - up to 3 weeks. Unidox is taken 200 mg orally once a day.

Other Applications
To prevent the development of postoperative infectious complications, after an abortion in the first trimester of pregnancy, in the presence of PID (pelvic inflammatory disease), multiple sexual partners, or a history of gonorrhea, take 100 mg of Unidox 1 hour before surgery, and 200 mg of the drug after 1.5 hours after an abortion.

For children
For children over 8 years of age, Unidox is prescribed in a daily dose of 5 mg per 1 kg of weight, but not more than 200 mg. The daily dose is divided into 2 doses.

Side effect

Adverse reactions from various organs and systems of the body when using the drug Unidox Solutab include the following symptoms:

The risk of developing pseudotumor cerebri increases when taking vitamin A supplements while using Unidox.

The reduced therapeutic effect of oral estrogen-containing contraceptives should also be taken into account.

special instructions

Unidox Solutab should be taken orally, preferably in a standing position, with plenty of water. This will prevent possible damage to the esophagus and irritation of the gastric and intestinal mucosa.

The drug is taken regardless of meals, but at regular intervals, without skipping or doubling the dose.

During treatment, it is necessary to refrain from exposure to the sun (under direct exposure).

Unidox can be used to treat patients with renal failure, as it is eliminated through the gastrointestinal tract.

Unidox Solutab during pregnancy

The drug penetrates the uteroplacental barrier and can contribute to severe disorders of bone tissue development in the fetus. Therefore, the use of Unidox Solutab is CONTRAINDICATED during pregnancy.

Combination with alcohol

When taking Unidox Solutab and alcohol simultaneously, their toxic effect on the liver increases, which can lead to the development of toxic hepatitis. The therapeutic effect of the drug is also reduced. Drinking alcohol is possible only a week after completing the course of treatment with Unidox.

Analogs

Preparations with a similar active ingredient (doxycycline):

• Dovicil;
• Doxycycline Nycomed;
• Bassada;
• Vidoccin;
• Doxibene;
• Vibramycil;
• Xedocin;
• Doxal;
• Monocline;
• Apo-doxy;
• Doxidar 100.

Storage conditions and periods

The drug is stored in a dry place at a temperature of 15 to 25 o C, out of reach of children.
The drug is considered fit for use within 5 years from the date of production.

Dispensing conditions in pharmacies

You can buy Unidox Solutab in the pharmacy chain upon presentation of a doctor's prescription for this drug.

Price

Price in Ukraine
Unidox Solutab soluble tablets can be bought in Ukraine at an average price of 68 hryvnia per pack.

Price in Russia
Dispersible antibiotic tablets Unidox Solutab 100 mg can be bought in Russia at an average price of 300 rubles per pack.

Contents [Show]

In this article you can read the instructions for using an antibacterial drug Unidox Solutab. Reviews of site visitors - consumers of this medicine, as well as the opinions of specialist doctors on the use of Unidox Solutab in their practice are presented. We kindly ask you to actively add your reviews about the drug: whether the medicine helped or did not help get rid of the disease, what complications and side effects were observed, perhaps not stated by the manufacturer in the annotation. Analogues of Unidox Solutab in the presence of existing structural analogues. Use for the treatment of bronchitis, otitis, ureaplasma and other infections, as well as acne in adults, children, as well as during pregnancy and lactation.

Unidox Solutab

Pharmacokinetics

Indications

• osteomyelitis;
• sepsis;
• peritonitis.

Release forms

Side effect

• anorexia;
• nausea, vomiting;
• dysphagia;
• diarrhea;
• enterocolitis;
• pseudomembranous colitis;
• photosensitivity;
• hives;
• angioedema;
• anaphylactic reactions;
• hemolytic anemia;
• thrombocytopenia;
• neutropenia;
• eosinophilia;

Contraindications

• porphyria;
• pregnancy;
• children under 8 years of age;

special instructions

Drug interactions

• Bassado;
• Vibramycin;
• Vidoccin;
• Dovitsin;
• Doxal;
• Doxibene;
• Doxilan;
• Doxycycline;
• Doxycycline Nycomed;
• Doxycycline Stad;
• Doxycycline-AKOS;
• Doxycycline hydrochloride;
• Xedocin;
• Monocline.

If there are no analogues of the drug for the active substance, you can follow the links below to the diseases for which the corresponding drug helps and look at the available analogues for the therapeutic effect.

Detailed instructions for use are published on this page. Unidox Solutaba. The available dosage forms of the drug (100 mg tablets), as well as its analogues, are listed. Information is provided on the side effects that Unidox Solutab can cause and on interactions with other medications. In addition to information about the diseases for the treatment and prevention of which the drug is prescribed (bronchitis, otitis media, ureaplasma and other infectious diseases), administration algorithms, possible dosages for adults and children are described in detail, and the possibility of use during pregnancy and breastfeeding is clarified. The abstract for Unidox Solutab is supplemented with reviews from patients and doctors. Interaction of the drug with alcohol.

Instructions for use and dosage regimen

It is preferable to take the drug with food. The tablets are dissolved in a small amount of water (about 20 ml) to obtain a suspension. The tablets can also be swallowed whole, split into pieces, or chewed with water. Usually the duration of treatment is 5-10 days.

Adults and children over 8 years of age weighing more than 50 kg are prescribed 200 mg per day in 1 or 2 doses on the first day of treatment, and 100 mg per day in 1 dose on subsequent days of treatment. In case of severe infections, 200 mg per day is prescribed for the entire treatment period.

For children aged 8-12 years with body weight less than 50 kg, the average daily dose is 4 mg/kg on the first day, then 2 mg/kg per day (in 1-2 doses). In cases of severe infections, the drug is prescribed at a dose of 4 mg/kg daily throughout treatment.

For infection caused by Streptococcus pyogenes, the duration of treatment is at least 10 days.

For uncomplicated gonorrhea (with the exception of anorectal infections in men), adults are prescribed 100 mg 2 times a day until complete cure (on average within 7 days), or 600 mg is prescribed for one day - 300 mg in 2 doses (second dose 1 hour after the first).

For primary syphilis, 100 mg is prescribed 2 times a day for 14 days, for secondary syphilis - 100 mg 2 times a day for 28 days.

For uncomplicated urogenital infections caused by Chlamydia trachomatis, cervicitis, non-gonococcal urethritis caused by Ureaplasma urealiticum, 100 mg is prescribed 2 times a day for 7 days.

For acne, 100 mg per day is prescribed, the course of treatment is 6-12 weeks.

To prevent malaria, 100 mg is prescribed once a day 1-2 days before the trip, then daily during the trip and for 4 weeks after returning; children over 8 years old - 2 mg/kg 1 time per day.

To prevent travelers' diarrhea - 200 mg on the first day of the trip in 1 or 2 doses, then 100 mg 1 time per day during the entire stay in the region (no more than 3 weeks).

For the treatment of leptospirosis - 100 mg orally 2 times for 7 days; for the prevention of leptospirosis - 200 mg once a week during your stay in a disadvantaged area and 200 mg at the end of the trip.

To prevent infections during medical abortion, 100 mg is prescribed 1 hour before and 200 mg after the intervention.

Maximum daily doses for adults are up to 300 mg per day or up to 600 mg per day for 5 days for severe gonococcal infections. For children over 8 years old weighing more than 50 kg - up to 200 mg, for children 8-12 years old weighing less than 50 kg - 4 mg/kg daily throughout treatment.

In case of renal (creatinine clearance less than 60 ml/min) and/or liver failure, a reduction in the daily dose of doxycycline is required.

Release forms

Dispersible tablets 100 mg.

Unidox Solutab- long-acting tetracycline (active ingredient - antibiotic doxycycline) with a wide spectrum of action. Acts bacteriostatically, inhibits protein synthesis in the microbial cell.

Active against gram-positive and gram-negative aerobic and anaerobic bacteria.

The possibility of acquired resistance to doxycycline in a number of pathogens, which is often cross-linked within a group, should be taken into account (i.e., strains resistant to doxycycline will simultaneously be resistant to the entire group of tetracyclines).

Pharmacokinetics

Absorption is fast and high (100%). Food intake has a slight effect on the absorption of the drug, which has no clinical significance. Doxycycline binds reversibly to plasma proteins (80-90%), penetrates well into tissues, poorly into the cerebrospinal fluid (10-20% of the concentration in the blood plasma), however, the concentration of doxycycline in the cerebrospinal fluid increases with inflammation of the spinal membrane. Doxycycline crosses the placental barrier and is secreted into breast milk in small quantities. Only a small portion of doxycycline is metabolized. Approximately 40% of the dose taken is excreted in a biologically active form by tubular secretion in the kidneys, 20-40% is excreted through the intestines in the form of inactive forms (chelates).

Indications

Infectious and inflammatory diseases caused by microorganisms sensitive to the drug:

• respiratory tract infections (including pharyngitis, acute bronchitis, exacerbation of chronic obstructive pulmonary disease, tracheitis, bronchopneumonia, lobar pneumonia, community-acquired pneumonia, lung abscess, pleural empyema);
• infections of the ENT organs (including otitis media, sinusitis, tonsillitis);
• infections of the genitourinary system (cystitis, pyelonephritis, bacterial prostatitis, urethritis, urethrocystitis, urogenital mycoplasmosis, acute orchiepididymitis; endometritis, endocervicitis and salpingoophoritis /as part of combination therapy/);
• sexually transmitted infections (urogenital chlamydia, syphilis in patients with penicillin intolerance, uncomplicated gonorrhea /as an alternative therapy/, granuloma inguinale, lymphogranuloma venereum);
• infections of the gastrointestinal tract and biliary tract (cholera, yersiniosis, cholecystitis, cholangitis, gastroenterocolitis, bacillary and amoebic dysentery, travelers' diarrhea);
• infections of the skin and soft tissues (including wound infections after animal bites), severe acne (as part of combination therapy);
• other diseases (yaws, legionellosis, chlamydia of various localizations / including prostatitis and proctitis/, rickettsiosis, Q fever, Rocky Mountain spotted fever, typhus / including typhus, tick-borne relapsing/, Lyme disease / stage 1 - erythema migrans/, tularemia, plague, actinomycosis, malaria, leptospirosis, psittacosis, ornithosis, anthrax /including pulmonary form/, bartonellosis, granulocytic ehrlichiosis, whooping cough, brucellosis);
• infectious eye diseases, as part of combination therapy - trachoma;
• osteomyelitis;
• sepsis;
• subacute septic endocarditis;
• peritonitis.

Prevention of postoperative purulent complications and malaria caused by Plasmodium falciparum during short-term travel (less than 4 months) to areas where strains resistant to chloroquine and/or pyrimethamine-sulfadoxine are common.

Contraindications

• severe impairment of liver and/or kidney function;
• porphyria;
• pregnancy;
• lactation period (breastfeeding);
• children under 8 years of age;
• hypersensitivity to antibiotics of the tetracycline group.

special instructions

There is a possibility of cross-resistance and hypersensitivity with other tetracycline drugs.

Tetracyclines may increase prothrombin time; the use of tetracyclines in patients with coagulopathies should be carefully monitored.

The anti-anabolic effect of tetracyclines can lead to an increase in the level of residual urea nitrogen in the blood. As a rule, this is not significant for patients with normal renal function. However, in patients with renal failure, an increase in azotemia may occur. The use of tetracyclines in patients with impaired renal function requires medical supervision.

With long-term use of the drug, periodic monitoring of laboratory blood parameters, liver and kidney function is required.

Due to the possible development of photodermatitis, it is necessary to limit insolation during treatment and for 4-5 days after it.

Long-term use of the drug Unidox Solutab can cause dysbiosis and, as a result, the development of hypovitaminosis (especially B vitamins).

To prevent dyspeptic symptoms, it is recommended to take the drug with meals.

Impact on the ability to drive vehicles and operate machinery

The specific effects on the ability to drive a car and operate machinery have not been studied.

Side effect

• anorexia;
• nausea, vomiting;
• dysphagia;
• diarrhea;
• enterocolitis;
• pseudomembranous colitis;
• photosensitivity;
• hives;
• angioedema;
• anaphylactic reactions;
• hemolytic anemia;
• thrombocytopenia;
• neutropenia;
• eosinophilia;
• candidiasis (glossitis, stomatitis, proctitis, vaginitis) as manifestations of superinfection.

Drug interactions

Due to the suppression of intestinal microflora by doxycycline, the prothrombin index decreases, which requires dose adjustment of indirect anticoagulants.

When doxycilline is combined with bactericidal antibiotics that disrupt cell wall synthesis (penicillins, cephalosporins), the effectiveness of the latter is reduced, which should be taken into account when treating meningitis and tonsillopharyngitis caused by Streptococcus pyogenes.

Doxycycline reduces the reliability of contraception and increases the frequency of acyclic bleeding when taking estrogen-containing hormonal contraceptives.

Ethanol (alcohol), barbiturates, rifampicin, carbamazepine, phenytoin, accelerating the metabolism of doxycycline, reduce its concentration in the blood plasma.

The simultaneous use of doxycycline and retinol increases intracranial pressure.

Analogues of the drug Unidox Solutab

Structural analogues of the active substance:

• Bassado;
• Vibramycin;
• Vidoccin;
• Dovitsin;
• Doxal;
• Doxibene;
• Doxilan;
• Doxycycline;
• Doxycycline Nycomed;
• Doxycycline Stad;
• Doxycycline-AKOS;
• Doxycycline hydrochloride;
• Xedocin;
• Monocline.

Use during pregnancy and breastfeeding

Unidox Solutab is contraindicated for use during pregnancy.

The drug is contraindicated for use during lactation (breastfeeding). Doxycycline is excreted in breast milk.

Instructions

(information for specialists)

According to the medical use of the drug

UNIDOX SOLUTION

Registration number: P N013102/01

Tradename: Unidox Solutab®

INN: Doxycycline

Dosage form: Dispersible tablets

Compound:
Active substance: doxycycline monohydrate 100.0 mg in terms of doxycycline
Excipients: microcrystalline cellulose, saccharin, hyprolose (low-substituted), hypromellose, colloidal silicon dioxide (anhydrous), magnesium stearate, lactose monohydrate

Description:
Round, biconvex tablets from light yellow to gray-yellow in color with “173” (tablet code) engraved on one side and a scored line on the other.

Pharmacotherapeutic group: Antibiotic - tetracycline

ATX code:

Pharmachologic effect:
Pharmacodynamics
Broad-spectrum antibiotic from the tetracycline group. It acts bacteriostatically, suppresses protein synthesis in the microbial cell by interacting with the 30S ribosomal subunit. Active against many gram-positive and gram-negative microorganisms: Streptococcus spp., Treponema spp., Staphylococcus spp., Klebsiella spp., Enterobacter spp. (including E. aerugenes), Neisseria gonorrhoeae, Neisseria meningitidis, Haemophilus influenzae, Chlamydia spp., Mycoplasma spp., Ureaplasma urealyticum, Listeria monocytogenes, Rickettsia spp., Typhus exanthematicus, Escherichia coli, Shigella spp., Campylobacter fetus, Vibrio cholerae, Yersinia spp. (including Yersinia pestis), Brucella spp., Francisella tularensis, Bacillus anthracis, Bartonella bacilliformis, Pasteurella multocida, Borrelia recurrentis, Clostridium spp. (except Clostridium difficile), Actinomyces spp., Fusobacterium fusiforme, Calymmatobacterium granulomatosis, Propionibacterium acnes, some protozoa (Entamoeba spp., Plasmodium falciparum).
As a rule, it has no effect on Acinetobacter spp., Proteus spp., Pseudomonas spp., Serratia spp., Providencia spp., Enterococcus spp.
The possibility of acquired resistance to doxycycline in a number of pathogens should be taken into account, which is often cross-resistance within the group (i.e., strains resistant to doxycycline will simultaneously be resistant to the entire group of tetracyclines).

Pharmacokinetics
Suction
Absorption is fast and high (about 100%). Food intake has little effect on the absorption of the drug.
The maximum level of doxycycline in the blood plasma (2.6-3 mcg/ml) is achieved 2 hours after taking 200 mg; after 24 hours, the concentration of the active substance in the blood plasma decreases to 1.5 mcg/ml.
After taking 200 mg on the first day of treatment and 100 mg per day on subsequent days, the plasma concentration of doxycycline is 1.5-3 mcg/ml.

Distribution
Doxycycline binds reversibly to plasma proteins (80-90%), penetrates well into organs and tissues, poorly into the cerebrospinal fluid (10-20% of the level in the blood plasma), however, the concentration of doxycycline in the cerebrospinal fluid increases with inflammation of the spinal membrane.
Volume of distribution - 1.58 l/kg. 30–45 minutes after oral administration, doxycycline is found in therapeutic concentrations in the liver, kidneys, lungs, spleen, bones, teeth, prostate gland, eye tissue, pleural and ascitic fluids, bile, synovial exudate, exudate of the maxillary and frontal sinuses, in gingival sulcus fluids.
With normal liver function, the level of the drug in bile is 5-10 times higher than in plasma.
In saliva, 5-27% of the concentration of doxycycline in blood plasma is determined.
Doxycycline crosses the placental barrier and is secreted into breast milk in small quantities.
Accumulates in dentin and bone tissue.

Metabolism
A small portion of doxycycline is metabolized.

Removal
The half-life after a single oral dose is 16-18 hours, after repeated doses it is 22-23 hours.
Approximately 40% of the drug taken is excreted by the kidneys and 20 - 40% is excreted through the intestines in the form of inactive forms (chelates).

Pharmacokinetics in special clinical situations
The half-life of the drug in patients with impaired renal function does not change, because its excretion through the intestines increases.
Hemodialysis and peritoneal dialysis do not affect the concentration of doxycycline in blood plasma.

Indications for use
Infectious and inflammatory diseases caused by sensitive
to the drug with microorganisms:

• respiratory tract infections, including pharyngitis, acute bronchitis, exacerbation of chronic obstructive pulmonary disease, tracheitis, bronchopneumonia, lobar pneumonia, community-acquired pneumonia, lung abscess, pleural empyema;
• infections of the ENT organs, including otitis media, sinusitis, tonsillitis;
• infections of the genitourinary system: cystitis, pyelonephritis, bacterial prostatitis, urethritis, urethrocystitis, urogenital mycoplasmosis, acute orchiepididymitis; endometritis, endocervicitis and salpingoophioritis as part of a combined therapy; including sexually transmitted infections: urogenital chlamydia, syphilis in patients with penicillin intolerance, uncomplicated gonorrhea (as an alternative therapy), granuloma inguinale, lymphogranuloma venereum;
• infections of the gastrointestinal tract and biliary tract (cholera, yersiniosis, cholecystitis, cholangitis, gastroenterocolitis, bacillary and amoebic dysentery, traveler's diarrhea);
• infections of the skin and soft tissues (including wound infections after animal bites), severe acne (as part of combination therapy);
• other diseases: yaws, legionellosis, chlamydia of various localizations (including prostatitis and proctitis), rickettsiosis, Q fever, Rocky Mountain spotted fever, typhus (including typhus, tick-borne relapsing), Lyme disease (I stage. - erythema migrans), tularemia, plague, actinomycosis, malaria; infectious eye diseases, as part of combination therapy - trachoma; leptospirosis, psittacosis, ornithosis, anthrax (including pulmonary form), bartonellosis, granulocytic ehrlichiosis; whooping cough, brucellosis, osteomyelitis; sepsis, subacute septic endocarditis, peritonitis;
• prevention of postoperative purulent complications; malaria caused by Plasmodium falciparum during short-term travel (less than 4 months) to areas where strains resistant to chloroquine and/or pyrimethamine-sulfadoxine are common.

Contraindications

• hypersensitivity to tetracyclines
• pregnancy
• lactation
• age up to 8 years
• severe liver and/or kidney dysfunction
• porphyria

Directions for use and doses
Usually the duration of treatment is 5-10 days. The tablets are dissolved in a small amount of water (about 20 ml) to obtain a suspension; they can also be swallowed whole, divided into pieces or chewed with water. Preferably taken with food.

Adults and children over 8 years old weighing more than 50 kg Prescribe 200 mg in 1-2 doses on the first day of treatment, then 100 mg daily. In cases of severe infections, Unidox is prescribed at a dose of 200 mg daily throughout treatment.
Children 8-12 years old weighing less than 50 kg the average daily dose is 4 mg/kg on the first day, then 2 mg/kg per day (in 1-2 doses). In cases of severe infections, Unidox is prescribed at a dose of 4 mg/kg daily throughout treatment.

Features of dosing for certain diseases
For infection caused by S.pyogenes, Unidox is taken for at least 10 days.
For uncomplicated gonorrhea (excluding anorectal infections in men):
Adults are prescribed 100 mg twice a day until complete cure (on average within 7 days), or 600 mg is prescribed for one day - 300 mg in 2 doses (the second dose 1 hour after the first).

For primary syphilis, 100 mg is prescribed twice a day for 14 days, for secondary syphilis - 100 mg twice a day for 28 days.

For uncomplicated urogenital infections caused by Chlamydia trachomatis, cervicitis, non-gonococcal urethritis caused by Ureaplasma urealiticum, 100 mg is prescribed 2 times a day for 7 days.

For acne, 100 mg/day is prescribed, the course of treatment is 6-12 weeks.

Malaria (prevention): 100 mg 1 time per day 1-2 days before the trip, then daily during the trip and for 4 weeks after return; for children over 8 years old, 2 mg/kg 1 time per day.

“Travelers’ diarrhea” (prevention) – 200 mg on the first day of the trip (at one dose or 100 mg 2 times a day), then 100 mg 1 time per day throughout your stay in the region (no more than 3 weeks).

Treatment of leptospirosis - 100 mg orally 2 times a day for 7 days; prevention of leptospirosis - 200 mg once a week during your stay in a disadvantaged area and 200 mg at the end of the trip.

To prevent infections during medical abortion, 100 mg is prescribed 1 hour before and 200 mg after the intervention.

Maximum daily doses for adults are up to 300 mg/day or up to 600 mg/day for 5 days for severe gonococcal infections. For children over 8 years old weighing more than 50 kg - up to 200 mg, for children 8-12 years old weighing less than 50 kg - 4 mg/kg daily throughout treatment.

In the presence of renal (creatinine clearance less than 60 ml/min) and/or liver failure, a reduction in the daily dose of doxycycline is required, since this leads to a gradual accumulation of it in the body (risk of hepatotoxicity).

Side effects
From the gastrointestinal tract:
anorexia, nausea, vomiting, dysphagia, diarrhea, enterocolitis, pseudomembranous colitis.

Dermatological and allergic reactions: urticaria, photosensitivity, angioedema, anaphylactic reactions, exacerbation of systemic lupus erythematosus, maculopapular and erythematous rash, pericarditis, exfoliative dermatitis.

From the liver:
liver damage (with long-term use of the drug or in patients with renal or liver failure).

From the kidneys: an increase in residual urea nitrogen due to the anti-anabolic effect of the drug.

From the hematopoietic system:
hemolytic anemia, thrombocytopenia, neutropenia, eosinophilia, decreased prothrombin activity.

From the nervous system:
benign increase in intracranial pressure (anorexia, vomiting, headache, papilledema), vestibular disorders (dizziness or unsteadiness).

From the thyroid gland:
In patients receiving long-term doxycycline, reversible dark brown discoloration of the thyroid tissue is possible.

For teeth and bones:
doxycycline slows down osteogenesis, disrupts the normal development of teeth in children (the color of teeth irreversibly changes, enamel hypoplasia develops).

Other:
candidiasis (stomatitis, glossitis, proctitis, vaginitis) as a manifestation of superinfection.

Overdose Symptoms: Increased adverse reactions caused by liver damage - vomiting, fever, jaundice, azotemia, increased transaminase levels, increased prothrombin time.

Treatment: Immediately after taking large doses, gastric lavage, drinking plenty of fluids, and, if necessary, inducing vomiting are recommended. Take activated carbon and osmotic laxatives. Hemodialysis and peritoneal dialysis are not recommended due to low efficiency.

Drug interactions
Antacids containing aluminum, magnesium, calcium, iron preparations, sodium bicarbonate, magnesium-containing laxatives reduce the absorption of doxycycline, so their use should be separated by an interval of 3 hours.
Due to the suppression of intestinal microflora by doxycycline, the prothrombin index decreases, which requires dose adjustment of indirect anticoagulants.
When doxycycline is combined with bactericidal antibiotics that interfere with cell wall synthesis (penicillins, cephalosporins), the effectiveness of the latter is reduced.
Doxycycline reduces the reliability of contraception and increases the frequency of acyclic bleeding when taking estrogen-containing hormonal contraceptives.
Ethanol, barbiturates, rifampicin, carbamazepine, phenytoin and other stimulants of microsomal oxidation, accelerating the metabolism of doxycycline, reduce its concentration in the blood plasma.
The simultaneous use of doxycycline and retinol increases intracranial pressure.

special instructions
There is a possibility of cross-resistance and hypersensitivity with other tetracycline drugs.
Tetracyclines may increase prothrombin time; the use of tetracyclines in patients with coagulopathies should be carefully monitored.
The anti-anabolic effect of tetracyclines can lead to an increase in the level of residual urea nitrogen in the blood. As a rule, this is not significant for patients with normal renal function. However, in patients with renal failure, an increase in azotemia may occur. The use of tetracyclines in patients with impaired renal function requires medical supervision.
With long-term use of the drug, periodic monitoring of laboratory blood parameters, liver and kidney function is required.
Due to the possible development of photodermatitis, it is necessary to limit insolation during treatment and for 4-5 days after it.
Long-term use of the drug can cause dysbacteriosis and, as a result, the development of hypovitaminosis (especially B vitamins).
To prevent dyspeptic symptoms, it is recommended to take the drug with meals.

Features of the influence on the ability to drive a car and operate machinery have not been studied.

Release form
Dispersible tablets 100 mg; 10 tablets in a PVC/aluminum foil blister. 1 blister along with instructions for use in a cardboard box.

Storage conditions
At temperatures from 15 to 25 ºС.
Keep out of the reach of children!

Best before date
5 years.
Do not use after the expiration date stated on the packaging.

Conditions for dispensing from pharmacies
On prescription.

Produced:

Elisabethof 19, Leiderdorp

Packaged and/or packaged:
Astellas Pharma Europe B.V., Netherlands
or ZAO ORTAT, Russia

Consumer complaints should be sent to:
Moscow representative office of Astellas Pharma Europe B.V., the Netherlands:
109147 Moscow, Marksistskaya st. 16
"Mosalarco Plaza-1" business center, floor 3

Tradename

Unidox Solutab (Unidox Solutab).

International Nonproprietary Name (INN)

Doxycycline

Pharmacological group

Unidox Solutab belongs to the group

antibiotics tetracycline series.

Compound

One Unidox tablet contains doxycycline monohydrate in an amount equal to 100 mg of pure doxycycline - this is the active substance of Unidox Solutab tablets. Excipients:

• hyprolose (low-substituted);
• magnesium stearate;
• microcrystalline cellulose;
• hypromellose;
• saccharin;
• lactose monohydrate;
• colloidal silicon dioxide (anhydrous).

The tablets are packaged in plastic blisters of 10 pieces, one in a cardboard box.

Release form

The drug Unidox Solutab is available in the form of dispersible (soluble) biconvex round tablets. The color can be different shades of yellow. A notch is visible on one side of the tablet, and “173” is engraved on the other.

pharmachologic effect

Doxycycline, which is part of Unidox, is a substance that stops the proliferation of bacterial cells, which is associated with a violation of protein formation in the cells of microorganisms.

This drug belongs to the group of broad-spectrum antibiotics, but it should be noted that many microorganisms have currently become insensitive to this antibiotic.

In our time, the most sensitive to Unidox among gram-positive cocci are pneumococcus, most enterococci and some groups of staphylococci, and among gram-negative cocci - moraxella and meningococcus. Most gonococci are insensitive.

Doxycycline is active against leptospira, rickettsia, spirochetes, chlamydia, borrelia, mycoplasma, some protozoa and actinomycetes.

The destructive effect of doxycycline has been established against certain types of gram-positive and gram-negative bacilli: yersinia, listeria, brucella, vibrios (including cholera), pathogens of plague, granuloma inguinale, tularemia, anthrax.

Salmonella, Enterobacter, E. coli, Klebsiella, Shigella are resistant to doxycycline.

Among anaerobic microorganisms, fusobacteria, clostridia, and propionibacteria (P. acnes) are susceptible to the action of doxycycline.

Pharmacokinetics

When taken orally, it is perfectly absorbed, and its absorption and effect in the body does not depend on food intake. In the period from an hour to 3 hours after taking the drug, the maximum concentration of doxycycline is recorded in the blood. This drug also creates a fairly high concentration of doxycycline in the tissues. In the cerebrospinal fluid, the level of the drug is 25% higher than in the blood, in bile – 20%. The drug is able to penetrate the placenta to the fetus and enter the

breast milk

It is eliminated from the body through the gastrointestinal tract. The period during which exactly half the dose of the drug taken is eliminated from the body is 20 hours.

Application

The drug Unidox Solutab has found wide use in the treatment of diseases such as:

• STIs (sexually transmitted infections) – gonorrhea, syphilis, lymphogranuloma venereum, granuloma inguinale;
• chlamydial infections - trachoma, urethritis, cervicitis, psittacosis, prostatitis;
• mycoplasma infections;
• rosacea (rosacea);
• acne;
• borreliosis – relapsing fever, Lyme disease;
• bacterial zoonotic infections – tularemia, plague, brucellosis, anthrax, leptospirosis;
• rickettsiosis;
• lower respiratory tract infections - community-acquired atypical pneumonia, chronic bronchitis in the acute stage;
• gynecological infectious diseases – salpingoophoritis, adnexitis, endometritis;
• actinomycosis;
• acute dacryocystitis;
• intestinal infectious diseases – yersiniosis, cholera;
• animal bites complicated by wound infection;
• cat scratch disease;
• prevention of tropical malaria.

Contraindications

• children under 8 years of age;
• severe liver pathology;
• pregnancy;
• lactation period.

Instructions for use Pimples (acne, acne vulgaris, rosacea) In case of intolerance and ineffectiveness of local treatment of acne, in case of severe and moderate course of the disease (including scar formation), systemic antibiotic therapy is prescribed. In this case, the antibiotic Unidox is the drug of choice. Take 100-200 mg of the drug, dividing the dose into 2 doses. The duration of treatment is 12 days.

Ureaplasmosis Treatment of ureaplasmosis is carried out by taking 100 mg of the drug Unidox twice a day with a 12-hour break, for 7 days.

Chlamydia For the treatment of urogenital chlamydia, Unidox is taken 100 mg twice a day for a week.

Prostatitis The duration of treatment of bacterial prostatitis with Unidox at a daily dose of 200 mg is at least 4 weeks. The drug is taken in two doses, 12 hours apart.

Syphilis In case of intolerance to penicillin antibiotics, reserve antibiotics are used in the treatment of syphilis, one of which is Unidox Solutab. For preventive treatment, the drug is prescribed 3 times a day, 100 mg, for 2 weeks. For the treatment of fresh forms, the period of use of the drug at the same dose is increased to 20-25 days.

Gonorrhea Uncomplicated subacute and acute forms of gonorrhea can be treated with Unidox Solutab. Tablets are taken orally at 100 mg (the first dose is 200 mg) every 12 hours, the total dose of treatment is 1000 mg. For other forms of gonorrhea, treatment is carried out according to the same scheme, but the total dose per course is 1500 mg.

Granuloma For the treatment of lymphogranuloma venereum and inguinal granuloma (donovanosis), Unidox tablets are taken for 3 weeks, 100 mg every 12 hours.

Actinomycosis Actinomycosis can be treated with Unidox in a daily dose of 0.2 g, taken for six months to a year.

Eye diseases Eye diseases, such as trachoma and acute dacryocystitis, are treated with Unidox for 21-28 days at a daily dose of 200 mg, in two doses.

Cholera For cholera, 300 mg of Unidox is prescribed once.

Rickettsial disease The treatment regimen for rickettsiosis includes prescribing Unidox 100 mg twice a day for a week (or for 2 days after normalization of body temperature).

Zoonosis The treatment regimen for bacterial zoonoses is similar, the only differences are in the duration of drug administration. Unidox is prescribed 100 mg every 12 hours, for plague - 10 days, for tularemia - 2 weeks, for anthrax - 2 months.

Brucellosis The treatment regimen for brucellosis also includes the administration of Unidox 100 mg twice a day, in combination with other antimicrobial drugs (streptomycin, rifampicin).

Leptospirosis To prevent leptospirosis, take 100 mg of Unidox once a week.

For tick-borne

borreliosis

For a month, take 0.1 g of the drug every 12 hours. For prevention purposes, 200 mg of Unidox is prescribed once.

Malaria When traveling to areas where malaria is endemic, you must take Unidox the day before departure, and take the drug during the entire period of your stay in this country. The total interval for taking Unidox should not exceed 6 months. The daily dose is 100 mg.

Respiratory system infections For lower respiratory tract infections, the duration of Unidox therapy is from 7 to 10 days, for mycoplasma pneumonia - up to 3 weeks. Unidox is taken 200 mg orally once a day.

Other Applications To prevent the development of postoperative infectious complications, after an abortion in the first trimester of pregnancy, in the presence of PID (pelvic inflammatory disease), multiple sexual partners, a history of gonorrhea, take 100 mg of Unidox 1 hour before surgery, and 200 mg of the drug after 1.5 hours after an abortion.

For children For children over 8 years of age, Unidox is prescribed in a daily dose of 5 mg per 1 kg of weight, but not more than 200 mg. The daily dose is divided into 2 doses.

Side effect Adverse reactions from various organs and systems of the body when using the drug Unidox Solutab include the following symptoms:

• nausea and vomiting, abdominal pain, diarrhea, glossitis with blackening of the tongue and hypertrophy of the papillae, esophagitis, inflammation of the pancreas, erosion of the esophagus, inflammation of the large intestine, disruption of the intestinal and vaginal microflora, fungal infections;
• pseudotumor cerebri syndrome with long-term use (increased intracranial pressure), dizziness;
• dysfunction of the liver up to the appearance of liver necrosis;
• urticaria, Quincke's edema, itchy rash, anaphylactic shock;
• photosensitivity (under the influence of direct sunlight, dermatitis and rash appear on the skin);
• the appearance of defects in tooth enamel, discoloration of teeth in a gray-brown or yellow color.

Overdose (symptoms) When taking large doses of the drug, nausea, vomiting, increased body temperature, yellowness of the skin, and bleeding may occur.

If these symptoms are observed, gastric lavage is necessary. You should also take activated charcoal and laxatives. Drinking plenty of fluids is recommended.

Interaction with other drugs

Reduces bioavailability

antacids

- drugs containing

Cholestyramine, magnesium, aluminum, sodium bicarbonate. There should be a break of at least 1 hour between taking Unidox and these drugs.

The absorption of both drugs is impaired when Unidox is prescribed simultaneously with iron supplements.

Barbiturates, phenytoin and carbamazepine increase the breakdown of doxycycline in the liver and reduce its concentration in the blood, which may require dosage adjustment of Unidox.

Unidox may enhance the medicinal effect of indirect coagulants when taken simultaneously; monitoring of prothrombin time is necessary.

The risk of developing pseudotumor cerebri increases when taking vitamin A supplements while using Unidox.

The reduced therapeutic effect of oral estrogen-containing contraceptives should also be taken into account.

special instructions

Unidox Solutab should be taken orally, preferably in a standing position, washed down with a large amount

This will prevent possible damage to the esophagus and irritation of the gastric and intestinal mucosa.

The drug is taken regardless of meals, but at regular intervals, without skipping or doubling the dose.

During treatment, it is necessary to refrain from exposure to the sun (under direct exposure).

Unidox can be used to treat patients with renal failure, as it is eliminated through the gastrointestinal tract.

Unidox Solutab during pregnancy

The drug penetrates the uteroplacental barrier and can contribute to severe disorders of bone tissue development in the fetus. Therefore, the use of Unidox Solutab is CONTRAINDICATED during

pregnancy

Combination with alcohol

When taking Unidox Solutab and alcohol simultaneously, their toxic effect on the liver increases, which can lead to the development of toxic

hepatitis A

The therapeutic effect of the drug is also reduced. Drinking alcohol is possible only a week after completing the course of treatment with Unidox.

Analogs Preparations with a similar active ingredient (doxycycline):

• Dovicil;
• Doxycycline Nycomed;
• Bassada;
• Vidoccin;
• Doxibene;
• Vibramycil;
• Xedocin;
• Doxal;
• Monocline;
• Apo-doxy;
• Doxidar 100.

Storage conditions and periods

The drug is stored in a dry place at a temperature of 15 to 25

C, in a place inaccessible to children.

The drug is considered fit for use within 5 years from the date of production.

Dispensing conditions in pharmacies

You can buy Unidox Solutab in the pharmacy chain upon presentation of a doctor's prescription for this drug.

Price Price in Ukraine Unidox Solutab soluble tablets can be bought in Ukraine at an average price of 68 hryvnia per pack.

Price in Russia Dispersible antibiotic tablets Unidox Solutab 100 mg can be bought in Russia at an average price of 300 rubles per pack.

The drug Unidox Solutab is an antibiotic agent of the tetracycline group with a wide spectrum of antimicrobial effects. The medication is applicable for the treatment of many infectious lesions of various body systems caused by pathogenic microorganisms sensitive to the action of the active component. The product has a pronounced bacteriostatic effect. Unidox Solutab can be taken from 8 years of age, which significantly expands the therapeutic capabilities of the medication. To achieve the most effective result, you should entrust the calculation of individual dosages to a qualified specialist.

Dosage form

The antimicrobial agent Unidox Solutab is available in the form of round grayish-yellow biconvex dispersible tablets with the engraved code “173” on one side and a notched dividing strip on the other.

The medication is packaged in cardboard packs containing one blister of 10 tablets.

Description and composition

The active ingredient of the antibiotic Unidox Solutab is represented by monohydrate. Each medicinal unit contains 100 mg of the active element.

The excipients are:

• anhydrous silica;
• magnesium stearate;
• hypromellose;
• lactose monohydrate;
• saccharin;
• microcrystalline cellulose.

Pharmacological group

Unidox Solutab belongs to the group of tetracycline antimicrobial drugs with a pronounced bacteriostatic effect. Drug activity consists of disrupting metabolic processes and interrupting protein synthesis in the cell membranes of pathogenic microorganisms. In addition, the substance helps break the bonds of certain types of RNA with ribosomal membranes. exhibits increased activity against developing and dividing bacteria. The product has virtually no effect on microflora that are at rest. The bacteriostatic effect is observed against a wide range of pathogenic microorganisms. Some gram-positive, gram-negative and various bacteria that cause sexually transmitted infections are susceptible to the action.

Unidox Solutab exhibits a high degree of absorption from the gastrointestinal tract, which is not affected by food intake. The possibility of binding to serum proteins averages 90%. The concentration of the active substance in plasma reaches a maximum 2–3 hours after oral administration.

Hepatic metabolism produces both active and inactive metabolites. Excretion of active metabolic products in unchanged form occurs in the urine, while inactive metabolites are excreted in feces. The half-life is 16 to 18 hours. When taking the medicine again, this time increases by 3-4 hours.

The active substance of Unidox Solutab can penetrate the placental barrier and enter breast milk. The medication accumulates in the tissues of the prostate gland.

Indications for use

The drug is prescribed for the treatment of infectious diseases caused by a wide range of pathogenic microorganisms susceptible to the action.

for adults

Infections of the gastrointestinal tract and biliary tract:

• traveler's diarrhea;
• cholera;
• cholecystitis;
• amoebic dysentery;
• cholangitis;
• gastroenterocolitis.

Infections of the genitourinary system:

• urethritis;
• chlamydia;
• syphilis;
• gonorrhea (as an alternative treatment);
• lymphogranuloma of a venereal nature;
• urogenital mycoplasmosis;
• prostatitis of a bacterial nature.

ENT infections:

• sinusitis;
• tonsillitis.

Other infections:

• acute degree of infectious;
• malaria;
• severe form of acne;
• infectious lesions after animal bites;
• plague;
• peritonitis;
• whooping cough;
• lung abscess;
• actinomycosis;
• eye infections;
• sepsis.

for children

Children under the age of 8 years are prohibited from using Unidox Solutab due to the extremely negative effect of the active element of the drug on the growth and development of the child’s skeletal bones and teeth.

The medication may pass into breast milk. If it is necessary to use the drug during lactation, it is necessary to stop breastfeeding.

During pregnancy, the use of the product is strictly prohibited due to the possibility of passing through the placenta.

Contraindications

• age group of patients up to 8 years;
• pregnancy and GC period;
• acute form of renal and/or liver failure;
• increased sensitivity of the patient's body to tetracyclines.

Applications and dosages

For the fastest and most effective achievement of therapeutic goals, it is recommended to draw up the average daily dosage and medication regimen together with your doctor.

The tablets can be taken either whole or crushed. You should drink the product with plenty of clean water.

for adults

Adult patients and children over 8 years of age whose body weight exceeds 50 kg are prescribed an initial dose of Unidox Solutab at a dosage of 100 mg 2 times a day or 200 mg 1 time a day. From the second day until the end of the course, the average daily dose should be 100 mg. For severe types of diseases, the initial dosage remains unchanged.

for children

The use of the drug for children under 8 years of age is strictly contraindicated.

For the age group over 8 years old, with a body weight of no more than 50 kg, it is recommended to take the medication in the following dosages:

• on the first day, the dose should be 4 mg for each kg of the child’s weight;
• the following doses of medication are 2 mg per kg of weight.

In the case of severe infectious pathologies, the initial dosage does not change throughout the entire therapeutic course.

for pregnant women and during lactation

The use of this medication is contraindicated for pregnant and lactating women. If it is necessary to use it during breastfeeding, you should immediately stop feeding the baby breast milk.

Side effects

• decrease in prothrombin time;
• nausea;
• development of candidiasis diseases;
• various stool disorders;
• dermatitis;
• thrombocytopenia;
• inflammation of the tongue;
• increased intracranial pressure;
• the appearance of an itchy rash on the skin;
• dizziness;
• enterocolitis;
• increased sensitivity to ultraviolet or visible radiation;
• Quincke's edema;
• anemia.

Interaction with other drugs

The use of Unidox Solutab in combination with cephalosporins, penicillin antibiotics and other drugs that have a bactericidal effect is contraindicated.

It is also undesirable to use it simultaneously with antacids and other metal-containing drugs due to the possibility of the formation of inactive compounds due to a chemical reaction.

The prothrombin index may change when used together with anticoagulants.

Colestipol and cholestyramine reduce the absorption of the drug.

When taken simultaneously with retinol, a significant increase in intracranial pressure is possible.

The medication reduces the effectiveness of oral contraceptives and increases the frequency of uterine bleeding that occurs due to their use.

special instructions

If the patient has various renal dysfunctions, no additional adjustments to drug dosages are required.

The medication can cause underdevelopment of tooth enamel and significantly slow down the longitudinal growth of skeletal bones in children under 8 years of age.

In case of liver diseases, special care must be taken.

To prevent the irritating effect of the drug on the mucous membranes of the gastrointestinal tract, it is recommended to take the drug in the middle of the day with a sufficient amount of liquid.

Overdose

Symptoms of overdose with increased doses of Unidox Solutab are:

• diarrhea;
• seizures;
• anorexia;
• feeling dizzy;
• nausea;
• pain in the head.

If signs of intoxication occur, you must immediately take a sufficient amount of enterosorbents, rinse the stomach and begin symptomatic treatment.

Analogs

Instead of Unidox Solutab, the following drugs can be used:

1. - a domestic drug that is produced by a number of Russian companies. It is available for sale in capsules (allowed for patients over 12 years of age, whose weight is more than 45 kg) and lyophilisate from which an infusion solution is prepared (available from 8 years of age). The antibiotic is contraindicated in pregnant and lactating women.
2. Xedocin is a German drug that is a complete analogue of the drug Unidox Solutab. The antibiotic is produced in capsules, which are contraindicated in children under 8 years of age, pregnant women and breastfeeding women.
3. Vidoccin is a domestic medicine based on , which is produced in a lyophilisate and when diluted, a solution for intravenous administration is obtained. The medicine is prohibited for children under 8 years of age, pregnant and lactating women.
4. Minolexin is a substitute for the drug Unidox Solutab according to the pharmacological group. The antibiotic is produced in capsules, approved for children over 8 years of age and pregnant patients. It is recommended to interrupt breastfeeding while taking the medication.

Storage conditions

The medication should be stored in a dry, dark place at a temperature not exceeding 25 degrees. It is necessary to limit children's access to the drug.

Shelf life – 5 years.

Drug price

The cost of the medicine is on average 322 rubles. Prices range from 283 to 367 rubles.

Some facts about the product:

Instructions for use

Price in online pharmacy website: from 327

Pharmacological properties

The drug Unidox Solutab has an antibacterial and bacteriostatic effect; it is classified as a semi-synthetic antibiotic substance that has a wide spectrum of action and is part of the tetracycline group. The main active ingredient of the drug is doxycycline monohydrate, which blocks the production of protein compounds in microbial cells, thereby disrupting the connections of transport ribonucleic membranes. The drug Unidox exhibits increased activity when exposed to aerobic gram-negative and gram-positive bacteria. The exceptions are bacteria resistant to doxycycline: Pseudomonas aeruginosa, Proteus spp, Serratia spp, Bacteroides fragilis. The drug has rapid and complete absorption from the gastrointestinal tract and actively binds to protein compounds in the blood plasma. Eating food has virtually no effect on the absorption process of the active substance. The drug is excreted unchanged through urine and feces (during bile secretion).

Indications for use

The drug Unidox Solutab can be used for infectious and inflammatory diseases caused by pathogens that are sensitive to the active substance of the drug.

Respiratory system: inflammatory processes of the mucous membrane of the throat, bronchi, lungs, trachea, etc. And also during exacerbation of chronic obstructive pulmonary disease.

Genitourinary system: diseases associated with inflammatory processes in the bladder, kidneys, urethra, and female genital organs. And also for infectious diseases transmitted sexually.

Gastrointestinal tract: infectious and inflammatory processes of the stomach and intestines (cholera, dysentery, cholecystitis and others).

Skin: infectious and inflammatory diseases of the skin, as well as infections in wounds and severe forms of acne.

Diseases caused by chlamydia, legionella, plasmodia, salmonella, leptospira and other pathogens sensitive to doxycycline.

Preventive treatment of purulent inflammatory processes in the period after surgery.

Preventive therapy of malarial diseases.

Contraindications

Restrictions on the use of the medicine Unidox are:

The presence of individual intolerance or hypersensitivity to the components included in the structure of the drug or tetracycline antibiotics.

Functional liver or kidney pathologies in severe form.

Porphyrin disease.

The period of gestation and subsequent breastfeeding.

Age limit up to eight years.

Decrease in the concentration of leukocytes in the blood serum.

Dosage and method of use

The drug Unidox Solutab is taken orally, in which it is possible to divide the tablet into parts, chew it or dissolve it in water. The length of the therapeutic course is about five to seven days. The standard dose for patients over eight years of age and weighing more than fifty kilograms is 200 mg of the active substance on the first day, which can be divided into two doses. Subsequently, 100 mg daily. For severe infectious diseases - 200 mg daily. In pediatric patients, from eight to twelve years old, weighing less than 50 kilograms, use 4 mg per kilogram on the first day and then 2 mg per kilogram of weight. The dose can be divided into two doses. For severe infectious diseases – 4 mg/kg daily. Dosing for certain infectious diseases. In the case of gonorrheal disease, adult patients use 100 mg of the active substance twice a day, for a week, or if the treatment lasts one day, it is possible to use 600 mg of doxycycline at a time. The dose is divided into two doses with an interval of one hour. For syphilis disease (primary), 100 mg of the active substance is used twice a day, the duration of therapy is two weeks. For secondary disease, the course of treatment is extended to four weeks. For infectious diseases caused by chlamydia and ureplasma, in an uncomplicated form, use 100 mg of doxycycline twice a day. The duration of treatment is one week. Severe forms of acne - 100 mg per day for six to twelve weeks. For preventive measures against malaria, 100 mg is prescribed once a day, a few days before departure, then daily during the trip and for a four-week period after it. For pediatric patients over eight years of age, 2 mg per kilogram of body weight is prescribed, once a day. For leptospirosis, 100 mg of Unidox Solutab is prescribed twice a day, the duration of therapy is one week. For preventive treatment, 200 mg once every seven days until the end of your stay in disadvantaged areas. In the case of an operation to terminate a pregnancy, it is necessary to consume the active substance sixty minutes before surgery and 200 mg after it. The maximum daily doses for adult patients allowed for use are up to 600 mg per day for the treatment of severe infectious diseases. For pediatric patients over eight years of age and weighing more than fifty kilograms, 200 mg. Children from eight to twelve years old, weighing less than fifty kilograms - 4 mg per kilogram of weight. In the case of kidney pathologies, with creatinine clearance less than 60, as well as with liver failure, it is necessary to reduce the amount of the active substance.

Overdose

If a dose of the active substance is used greater than the maximum, it is possible to increase the negative symptoms of side effects that can be caused by liver intoxication:

state of vomiting,

effects of jaundice,

increased activity of liver enzymes,

increase in nitrogen content in the blood.

Therapy consists primarily of gastric lavage and inducing a gag reflex. Next, the patient must be given plenty of fluids, absorbents and laxatives with osmotic properties. Hemodialysis is ineffective.

Symptoms of side effects

Negative manifestations of side effects during therapy with the drug Unidox may be as follows. Gastrointestinal tract.

There may be a complete lack of appetite, nausea, vomiting, disorders of the swallowing mechanism, and digestive disorders. It is also possible to develop inflammatory processes in the intestinal mucous membranes.

Manifestation of allergic reactions.

Increased sensitivity to ultraviolet radiation, redness, peeling and inflammation of the skin, rash reactions, and Quincke's edema may develop.

Heart.

An inflammatory process of the serous membrane of the heart may occur.

Liver.

With long-term therapy, pathological changes in the liver may develop.

Kidneys.

The level of urea nitrogen compounds may increase. Hematopoietic system.

The concentration of platelets, neutrophils and prothrombin activity may decrease, the number of eisinophils may increase, and hemolytic anemia may develop.

Nervous system.

As pressure increases inside the skull, pain in the scalp, swelling of the optic nerves, vomiting and nausea may develop. Violations of the vestibule may also occur and associated states of dizziness and instability may occur.

Thyroid.

With prolonged use of the medical product Unidox Solutab, the thyroid tissue may turn brown. This effect is reversible. Bone apparatus and teeth.

The use of doxycycline drugs may interfere with the development of bones and teeth in children.

General.

Inflammatory processes in the oral cavity and genital organs are possible, as is the development of a super infectious disease.

These instructions for use cannot describe all the negative symptoms that may occur during the therapeutic course. Therefore, any discomfort should be reported to your doctor.

Drug interactions

Preparations that contain aluminum, magnesium, calcium, iron, and sodium substances can reduce the absorption process of the active substance. It is necessary to separate the time of using them with doxycycline at an interval of three hours. When used simultaneously with anticoagulant drugs, dose adjustment of the latter is required. When used together with antibiotics that interfere with the synthesis of cell walls, their effect may be reduced. Unidox may reduce the effectiveness of contraceptives. Concomitant use with retinol may increase intracranial pressure in the patient.

Use during pregnancy and breastfeeding

The drug has a negative effect on the intrauterine development of the fetus, affects the process of bone tissue formation, and also provokes the occurrence of fatty infiltrate in the liver. The product is prohibited for use in pregnant patients. If pregnancy occurs, you should immediately stop using doxycycline. If it is necessary to use the medicine during lactation, you should immediately stop breastfeeding.

Management of various modes of transport

Since one of the side effects is dizziness, it is recommended to be careful when driving a car or other vehicles. Also for carrying out work that requires increased attention and concentration.

Alcohol consumption

Alcohol should not be taken with drugs that have antibiotic properties. Because this can cause negative reactions, even severe ones.

Storage instructions

The storage requirements for the medical product Unidox Solutab require a temperature range of fifteen to twenty-five degrees Celsius. The product must be stored in its original packaging out of the reach of children and animals. If storage rules are followed, the shelf life is five years. After this period, the medicine cannot be used and must be disposed of.

Sales in pharmacy chains

The medicine can be purchased at pharmacy chains without presenting a prescription from a doctor.

Composition and release form

10 pcs in blister; 1 blister in a box.

Description of the dosage form

Round, biconvex tablets from light yellow to gray-yellow in color with “173” (tablet code) engraved on one side and a scored line on the other.

Characteristic

Broad-spectrum antibiotic from the tetracycline group.

pharmachologic effect

pharmachologic effect- bacteriostatic, antibacterial.

Suppresses protein synthesis in the microbial cell, disrupting the connection of transport RNAs of the ribosomal membrane.

Pharmacodynamics

Broad-spectrum antibiotic from the tetracycline group. It acts bacteriostatically, suppresses protein synthesis in the microbial cell by interacting with the 30S ribosomal subunit. Active against many gram-positive and gram-negative microorganisms: Streptococcus spp., Treponema spp., Staphylococcus spp., Klebsiella spp., Enterobacter spp.(including E. aerugenes), Neisseria gonorrhoeae, Neisseria meningitidis, Haemophilus influenzae, Chlamydia spp., Mycoplasma spp., Ureaplasma urealyticum, Listeria monocytogenes, Rickettsia spp., Typhus exanthematicus, Escherichia coli, Shigella spp., Campylobacter fetus, Vibrio cholerae, Yersinia spp. .(including Yersinia pestis), Brucella spp., Francisella tularensis, Bacillus anthracis, Bartonella bacilliformis, Pasteurella multocida, Borrelia recurrentis, Clostridium spp.(except Clostridium difficile), Actinomyces spp., Fusobacterium fusiforme, Calymmatobacterium granulomatis, Propionibacterium acnes, some protozoa (Entamoeba spp., Plasmodium falciparum).

Typically does not affect Acinetobacter spp., Proteus spp., Pseudomonas spp., Serratia spp., Providencia spp., Enterococcus spp.

The possibility of acquired resistance to doxycycline in a number of pathogens, which is often cross-linked within a group, should be taken into account (i.e., strains resistant to doxycycline will simultaneously be resistant to the entire group of tetracyclines).

Pharmacokinetics

Suction

Absorption is fast and high (about 100%). Food intake has little effect on the absorption of the drug.

Cmax of doxycycline in blood plasma (2.6-3 μg/ml) is achieved 2 hours after taking 200 mg; after 24 hours, the concentration of the active substance in blood plasma decreases to 1.5 μg/ml.

After taking 200 mg on the first day of treatment and 100 mg/day on subsequent days, the plasma concentration of doxycycline is 1.5-3 mcg/ml.

Distribution

Doxycycline binds reversibly to plasma proteins (80-90%), penetrates well into organs and tissues, poorly into the cerebrospinal fluid (10-20% of the level in blood plasma), however, the concentration of doxycycline in the cerebrospinal fluid increases with inflammation spinal membrane.

Volume of distribution - 1.58 l/kg. 30-45 minutes after oral administration, doxycycline is found in therapeutic concentrations in the liver, kidneys, lungs, spleen, bones, teeth, prostate gland, eye tissue, pleural and ascitic fluids, bile, synovial exudate, exudate of the maxillary and frontal sinuses, in gingival sulcus fluids.

With normal liver function, the level of the drug in bile is 5-10 times higher than in plasma.

In saliva, 5-27% of the concentration of doxycycline in blood plasma is determined.

Doxycycline crosses the placental barrier and is secreted into breast milk in small quantities.

Accumulates in dentin and bone tissue.

Metabolism

A small portion of doxycycline is metabolized.

Removal

T1/2 after a single oral dose is 16-18 hours, after repeated doses - 22-23 hours.

Approximately 40% of the drug taken is excreted by the kidneys and 20-40% is excreted through the intestines in the form of inactive forms (chelates).

Pharmacokinetics in special clinical situations

The half-life of the drug in patients with impaired renal function does not change, because its excretion through the intestines increases.

Hemodialysis and peritoneal dialysis do not affect the concentration of doxycycline in blood plasma.

Indications of the drug Unidox Solutab ®

Infectious and inflammatory diseases caused by microorganisms sensitive to the drug:

respiratory tract infections, incl. pharyngitis, acute bronchitis, exacerbation of COPD, tracheitis, bronchopneumonia, lobar pneumonia, community-acquired pneumonia, lung abscess, pleural empyema;

infections of ENT organs, incl. otitis media, sinusitis, tonsillitis;

infections of the genitourinary system (cystitis, pyelonephritis, bacterial prostatitis, urethritis, urethrocystitis, urogenital mycoplasmosis, acute orchiepididymitis; endometritis, endocervicitis and salpingoophoritis as part of combination therapy), incl. sexually transmitted infections (urogenital chlamydia, syphilis in patients with penicillin intolerance, uncomplicated gonorrhea (as an alternative therapy), granuloma inguinale, lymphogranuloma venereum);

infections of the gastrointestinal tract and biliary tract (cholera, yersiniosis, cholecystitis, cholangitis, gastroenterocolitis, bacillary and amoebic dysentery, travelers' diarrhea);

infections of the skin and soft tissues (including wound infections after animal bites), severe acne (as part of combination therapy);

other diseases (yaws, legionellosis, chlamydia of various localizations (including prostatitis and proctitis), rickettsiosis, Q fever, Rocky Mountain spotted fever, typhus (including typhus, tick-borne relapsing), Lyme disease (I stage. — erythema migrans), tularemia, plague, actinomycosis, malaria; infectious eye diseases (as part of combination therapy - trachoma); leptospirosis, psittacosis, ornithosis, anthrax (including pulmonary form), bartonellosis, granulocytic ehrlichiosis; whooping cough, brucellosis, osteomyelitis; sepsis, subacute septic endocarditis, peritonitis);

prevention of postoperative purulent complications;

prevention of malaria caused by Plasmodium falciparum for short-term travel (less than 4 months) to areas where strains resistant to chloroquine and/or pyrimethamine-sulfadoxine are common.

Contraindications

hypersensitivity to tetracyclines;

severe impairment of liver and/or kidney function;

porphyria;

pregnancy;

breast-feeding;

age up to 8 years.

Use during pregnancy and breastfeeding

Contraindicated during pregnancy. Breastfeeding should be stopped during treatment.

Side effects

From the gastrointestinal tract: anorexia, nausea, vomiting, dysphagia, diarrhea; enterocolitis, pseudomembranous colitis.

Dermatological and allergic reactions: urticaria, photosensitivity, angioedema, anaphylactic reactions, exacerbation of systemic lupus erythematosus, maculopapular and erythematous rash, pericarditis, exfoliative dermatitis.

From the liver: liver damage during long-term use or in patients with renal or hepatic impairment.

From the kidneys: increase in residual urea nitrogen (due to the anti-anabolic effect).

From the hematopoietic system: hemolytic anemia, thrombocytopenia, neutropenia, eosinophilia, decreased prothrombin activity.

From the nervous system: benign increase in intracranial pressure (anorexia, vomiting, headache, papilledema), vestibular disorders (dizziness or unsteadiness).

From the thyroid gland: In patients receiving long-term doxycycline, reversible dark brown discoloration of the thyroid tissue is possible.

For teeth and bones: doxycycline slows down osteogenesis, disrupts the normal development of teeth in children (the color of teeth irreversibly changes, enamel hypoplasia develops).

Other: candidiasis (stomatitis, glossitis, proctitis, vaginitis) as a manifestation of superinfection.

Interaction

Due to the suppression of intestinal microflora by doxycycline, the prothrombin index decreases, which requires dose adjustment of indirect anticoagulants.

When doxycycline is combined with bactericidal antibiotics that interfere with cell wall synthesis (penicillins, cephalosporins), the effectiveness of the latter is reduced.

Doxycycline reduces the reliability of contraception and increases the frequency of acyclic bleeding when taking estrogen-containing hormonal contraceptives.

Ethanol, barbiturates, rifampicin, carbamazepine, phenytoin and other stimulants of microsomal oxidation, accelerating the metabolism of doxycycline, reduce its concentration in the blood plasma.

The simultaneous use of doxycycline and retinol increases intracranial pressure.

Directions for use and doses

Inside, During meals, the tablet can be swallowed whole, divided into parts or chewed, washed down with a glass of water, or diluted in a small amount of water (about 20 ml).

Usually the duration of treatment is 5-10 days.

Adults and children over 8 years of age weighing more than 50 kg - 200 mg in 1-2 doses on the first day of treatment, then 100 mg daily. In cases of severe infections - at a dose of 200 mg daily throughout treatment.

For children 8-12 years old weighing less than 50 kg, the average daily dose is 4 mg/kg on the first day, then 2 mg/kg per day (in 1-2 doses). In cases of severe infections - at a dose of 4 mg/kg daily throughout treatment.

Features of dosing for certain diseases

For an infection caused by S.pyogenes, Unidox Solutab ® is taken for at least 10 days.

For uncomplicated gonorrhea (except for anorectal infections in men): adults - 100 mg 2 times a day until complete cure (on average within 7 days), or 600 mg - 300 mg in 2 doses are prescribed for one day (second taken 1 hour after the first).

For primary syphilis - 100 mg 2 times a day for 14 days, for secondary syphilis - 100 mg 2 times a day for 28 days.

For uncomplicated urogenital infections caused by Chlamydia trachomatis, cervicitis, non-gonococcal urethritis caused by Ureaplasma urealyticum,- 100 mg 2 times a day for 7 days.

For acne - 100 mg/day; course of treatment - 6-12 weeks.

Malaria (prevention) - 100 mg 1 time per day 1-2 days before the trip, then daily during the trip and for 4 weeks after returning; children over 8 years old - 2 mg/kg 1 time per day.

Travelers' diarrhea (prevention) - 200 mg on the first day of the trip in 1 or 2 doses, then 100 mg 1 time per day during the entire stay in the region (no more than 3 weeks).

Treatment of leptospirosis - 100 mg orally 2 times a day for 7 days; prevention of leptospirosis - 200 mg once a week during your stay in a disadvantaged area and 200 mg at the end of the trip.

To prevent infections during medical abortion - 100 mg 1 hour before and 200 mg after the intervention.

Maximum daily doses for adults are up to 300 mg/day or up to 600 mg/day for 5 days for severe gonococcal infections. For children over 8 years old weighing more than 50 kg - up to 200 mg, for children 8-12 years old weighing less than 50 kg - 4 mg/kg daily throughout treatment.

In the presence of renal (Cl creatinine<60 мл/мин) и/или печеночной недостаточности требуется снижение суточной дозы доксициклина, поскольку при этом происходит постепенное накопление его в организме (риск гепатотоксического действия).

Overdose

Symptoms: increased adverse reactions caused by liver damage (vomiting, fever, jaundice, azotemia, increased transaminase levels, increased PT).

Treatment: Immediately after taking large doses, gastric lavage, drinking plenty of fluids, and, if necessary, inducing vomiting are recommended. Activated carbon and osmotic laxatives are prescribed. Hemodialysis and peritoneal dialysis are not recommended due to low efficiency.

special instructions

There is a possibility of cross-resistance and hypersensitivity to other tetracycline drugs.

Tetracyclines may increase PT; the use of tetracyclines in patients with coagulopathies should be carefully monitored.

The anti-anabolic effect of tetracyclines can lead to an increase in the level of residual urea nitrogen in the blood. As a rule, this is not significant for patients with normal renal function. However, in patients with renal failure, an increase in azotemia may occur. The use of tetracyclines in patients with impaired renal function requires medical supervision.

With long-term use of the drug, periodic monitoring of laboratory blood parameters, liver and kidney function is required.

Due to the possible development of photodermatitis, it is necessary to limit insolation during treatment and for 4-5 days after it.

Long-term use of the drug can cause dysbacteriosis and, as a result, the development of hypovitaminosis (especially B vitamins).

To prevent dyspeptic symptoms, it is recommended to take the drug with meals.

The specific effects on the ability to drive a car and operate machinery have not been studied.

Storage conditions for the drug Unidox Solutab ®

At a temperature of 15-25 °C.

Keep out of the reach of children.

Shelf life of Unidox Solutab ®

5 years.

Do not use after the expiration date stated on the package.

Synonyms of nosological groups

Category ICD-10	Synonyms of diseases according to ICD-10
A49.3 Mycoplasma infection, unspecified	Pulmonary infection caused by mycoplasma
	Mycoplasma infection
	Mycoplasma infections
	Mycoplasma meningoencephalitis
	Mycoplasmosis
	Urogenital infection caused by mycoplasma
	Urogenital mycoplasmosis
A53.9 Syphilis, unspecified	Syphilis
	Tertiary syphilis
A54 Gonococcal infection	Gonococcal infections
	Disseminated gonococcal infection
	Disseminated gonorrheal infection
A55 Chlamydial lymphogranuloma (venereal)	Granuloma venereum
	Lymphogranuloma venereum
	Venereal lymphopathy
	Lymphogranulomatosis venereum
	Lymphogranuloma inguinal
	Chlamydial lymphogranuloma
	Nicolas-Favre disease
	Inguinal lymphogranuloma
	Inguinal lymphogranuloma (inguinal ulceration, inguinal lymphogranulomatosis)
	Subacute inguinal purulent microporoadenitis
	Chlamydial lymphogranuloma
	Fourth venereal disease
A69.2 Lyme disease	Lyme Arthritis
	Backyard disease
	Borreliosis
	Lyme borreliosis
	Tick-borne borreliosis
	Lyme borreliosis
	Lyme disease
A70 Chlamydia psittaci infection	Bird lovers disease
	Poultry farmers disease
	Psittacosis
	Psittacosis
A75 Typhus	Bangalore
	Louse-borne typhus
	Mouse typhus
	Tabardillo
	Typhus
	Toulon typhus
H60 Otitis externa	ENT infections
	Infections of the external auditory canal
	Outer ear infections
	Acute catarrhal inflammation of the external auditory canal
H66 Suppurative and unspecified otitis media	Bacterial ear infections
	Inflammation of the middle ear
	ENT infections
	Infectious and inflammatory diseases of the ear
	Infectious diseases of the ENT organs with severe pain syndrome
	Ear infection
	Infectious otitis media
	Persistent inflammation of the middle ear in children
	Ear pain due to otitis media
H70 Mastoiditis and related conditions	Mastoiditis
J01 Acute sinusitis	Inflammation of the paranasal sinuses
	Inflammatory diseases of the paranasal sinuses
	Purulent-inflammatory processes of the paranasal sinuses
	Infectious and inflammatory disease of ENT organs
	Sinus infection
	Combined sinusitis
	Exacerbation of sinusitis
	Acute inflammation of the paranasal sinuses
	Acute bacterial sinusitis
	Acute sinusitis in adults
	Subacute sinusitis
	Acute sinusitis
	Sinusitis
J02.9 Acute pharyngitis, unspecified	Purulent pharyngitis
	Lymphonodular pharyngitis
	Acute nasopharyngitis
J03.9 Acute tonsillitis, unspecified (angina agranulocytic)	Angina
	Sore throat, alimentary-hemorrhagic
	Sore throat secondary
	Primary tonsillitis
	Sore throat follicular
	Sore throats
	Bacterial tonsillitis
	Throat infections
	Catarrhal sore throat
	Lacunar tonsillitis
	Acute sore throat
	Acute tonsillitis
	Tonsillitis
	Acute tonsillitis
	Tonsillar tonsillitis
	Follicular tonsillitis
	Follicular tonsillitis
J04 Acute laryngitis and tracheitis	Infectious and inflammatory disease of ENT organs
	Laryngitis
	Laryngitis acute
	Acute tracheitis
	Pharyngolaryngitis
J06 Acute upper respiratory tract infections of multiple and unspecified localization	Bacterial infections of the upper respiratory tract
	Pain due to colds
	Pain in infectious and inflammatory diseases of the upper respiratory tract
	Inflammatory disease of the upper respiratory tract
	Inflammatory diseases of the upper respiratory tract
	Inflammatory diseases of the upper respiratory tract with difficult to separate sputum
	Secondary infections with influenza
	Secondary infections due to colds
	Influenza conditions
	Upper respiratory tract infections
	Upper respiratory tract infections
	Respiratory tract infections
	ENT infections
	Infectious and inflammatory diseases of the upper respiratory tract
	Infectious and inflammatory diseases of the upper respiratory tract and ENT organs
	Infectious and inflammatory diseases of the upper respiratory tract in adults and children
	Infectious and inflammatory diseases of the upper respiratory tract
	Respiratory tract infection
	Qatar of the upper respiratory tract
	Catarrhal inflammation of the upper respiratory tract
	Catarrhal disease of the upper respiratory tract
	Catarrhal phenomena from the upper respiratory tract
	Cough in diseases of the upper respiratory tract
	Cough with a cold
	Fever due to influenza
	ARVI
	acute respiratory infections
	Acute respiratory infection with symptoms of rhinitis
	Acute respiratory infection
	Acute infectious-inflammatory disease of the upper respiratory tract
	Acute cold
	Acute respiratory disease
	Acute respiratory disease of influenza nature
	Sore throat or nose
	Cold
	Colds
	Colds
	Respiratory infection
	Respiratory diseases
	Respiratory infections
	Recurrent respiratory tract infections
	Seasonal colds
	Seasonal colds
	Frequent colds and viral diseases
J22 Acute respiratory infection of the lower respiratory tract, unspecified	Bacterial respiratory disease
	Bacterial lower respiratory tract infections
	Bacterial respiratory infections
	Viral respiratory disease
	Viral respiratory tract infections
	Inflammatory diseases of the respiratory tract
	Difficulty secreting sputum in acute and chronic respiratory diseases
	Respiratory tract infections
	Respiratory and lung infections
	Lower respiratory tract infections
	Lower respiratory tract infections
	Infectious inflammation of the respiratory tract
	Infectious diseases of the respiratory tract
	Infectious lung diseases
	Infectious diseases of the respiratory system
	Respiratory tract infection
	Cough with a cold
	Pulmonary infection
	Acute respiratory tract infection
	Acute respiratory viral infection
	Acute inflammatory disease of the respiratory tract
	Acute respiratory tract disease
	Respiratory infection
	Respiratory viral infections
	Respiratory syncytial virus infection in young children
	Respiratory diseases
	Respiratory infections
J31 Chronic rhinitis, nasopharyngitis and pharyngitis
	Inflammation of the nasal mucosa
	Infectious and inflammatory diseases of the ENT organs
	Year-round rhinitis
	Ozena
	Sore throat or nose
	Hyperplastic rhinitis
	Chronic rhinitis
	Pharyngoesophagitis
	Chronic bacterial rhinitis
J32 Chronic sinusitis	Allergic rhinosinusopathy
	Purulent sinusitis
	Catarrhal inflammation of the nasopharyngeal region
	Catarrhal inflammation of the paranasal sinuses
	Exacerbation of sinusitis
	Chronic sinusitis
J35.0 Chronic tonsillitis	Chronic sore throat
	Inflammatory diseases of the tonsils
	Chronic tonsillitis
	Tonsillar tonsillitis
	Chronic hypertrophic tonsillitis
J37 Chronic laryngitis and laryngotracheitis	Infectious and inflammatory disease of ENT organs
	Infectious and inflammatory diseases of the ENT organs
K62.8.1* Proctitis	Anusitis
	Atrophic proctitis
L08.9 Local infection of skin and subcutaneous tissue, unspecified	Soft tissue abscess
	Bacterial or fungal skin infection
	Bacterial skin infections
	Bacterial soft tissue infections
	Bacterial skin infections
	Bacterial skin lesions
	Viral skin infection
	Viral skin infections
	Fiber inflammation
	Inflammation of the skin at injection sites
	Inflammatory skin diseases
	Pustular skin disease
	Pustular skin diseases
	Purulent-inflammatory disease of the skin and soft tissues
	Purulent-inflammatory skin diseases
	Purulent-inflammatory diseases of the skin and its appendages
	Purulent-inflammatory diseases of soft tissues
	Purulent skin infections
	Purulent soft tissue infections
	Skin infections
	Infections of the skin and skin structures
	Skin infection
	Infectious skin diseases
	Skin infection
	Infection of the skin and its appendages
	Infection of the skin and subcutaneous structures
	Infection of the skin and mucous membranes
	Skin infection
	Skin bacterial infections
	Necrotizing subcutaneous infections
	Uncomplicated skin infections
	Uncomplicated soft tissue infections
	Superficial skin erosion with secondary infection
	Umbilical infection
	Mixed skin infections
	Specific infectious processes in the skin
	Superinfection of the skin
L70 Acne	Acne nodulocystica
	Acne
	Comedones
	Acne treatment
	Papular-pustular acne
	Papulopustular acne
	Papulopustular acne
	Pimples
	Acne
	Acne
	Acne
	Nodular cystic acne
	Nodular cystic acne
M60.0 Infectious myositis	Muscle abscess
	Soft tissue infections
	Infectious myositis
	Pyomyositis
	Specific infectious processes in soft tissues
M65 Synovitis and tenosynovitis	Inflammatory soft tissue disease
	Nonspecific tenosynovitis
	Acute tenosynovitis
	Edema syndrome in muscular-articular diseases
	Tenosynovitis
	Tenosynovitis (tenovaginitis)
	Tenosynovitis
	Tenosynovitis (tenosynovitis)
	Tenosynovitis
M65.0 Tendon sheath abscess	Soft tissue infections
M71.0 Abscess of bursa	Soft tissue infections
M71.1 Other infectious bursitis	Bacterial bursitis
	Infectious bursitis
	Soft tissue infections
N30 Cystitis	Exacerbation of chronic cystitis
	Acute bacterial cystitis
	Recurrent cystitis
	Urethrocystitis
	Fibrous cystitis
	Cystopyelitis
N34 Urethritis and urethral syndrome	Bacterial nonspecific urethritis
	Bacterial urethritis
	Bougienage of the urethra
	Gonococcal urethritis
	Gonorrheal urethritis
	Urethral infection
	Non-gonococcal urethritis
	Non-gonorrheal urethritis
	Acute gonococcal urethritis
	Acute gonorrheal urethritis
	Acute urethritis
	Urethral lesion
	Urethritis
	Urethrocystitis
N39.0 Urinary tract infection without established location	Asymptomatic bacteriuria
	Bacterial urinary tract infections
	Bacterial urinary tract infections
	Bacteriuria
	Bacteriuria asymptomatic
	Chronic latent bacteriuria
	Asymptomatic bacteriuria
	Asymptomatic massive bacteriuria
	Inflammatory disease of the urinary tract
	Inflammatory disease of the genitourinary tract
	Inflammatory diseases of the bladder and urinary tract
	Inflammatory diseases of the urinary system
	Inflammatory diseases of the urinary tract
	Inflammatory diseases of the urogenital system
	Fungal diseases of the urogenital tract
	Fungal infections of the urinary tract
	Urinary tract infections
	Urinary tract infections
	Urinary tract infections
	Urinary tract infections
	Urinary tract infections
	Urinary tract infections caused by enterococci or mixed flora
	Uncomplicated genitourinary tract infections
	Complicated urinary tract infections
	Infections of the genitourinary system
	Urogenital infections
	Urinary tract infections
	Urinary tract infection
	Urinary tract infection
	Urinary tract infection
	Urinary tract infection
	Urinary tract infection
	Urogenital tract infection
	Uncomplicated urinary tract infections
	Uncomplicated urinary tract infections
	Uncomplicated genitourinary tract infections
	Exacerbation of chronic urinary tract infection
	Retrograde kidney infection
	Recurrent urinary tract infections
	Recurrent urinary tract infections
	Recurrent urinary tract infections
	Mixed urethral infections
	Urogenital infection
	Urogenital infectious and inflammatory disease
	Urogenital mycoplasmosis
	Urological disease of infectious etiology
	Chronic urinary tract infection
	Chronic urinary tract infections
	Chronic infectious diseases of the urinary system
N41 Inflammatory diseases of the prostate gland	Prostate disease
	Genital infection
	Prostatitis
	Chronic nonspecific prostatitis
N49 Inflammatory diseases of the male genital organs, not elsewhere classified
	Bacterial infections of the genitourinary system
	Genital infections in men
	Urogenital infections
	Infectious lesions of the male genital tract
	Chronic inflammatory diseases of the pelvic organs
N71 Inflammatory diseases of the uterus, except the cervix	Intrauterine infections
	Inflammatory diseases of the female genitalia
	Inflammatory diseases of the female genital organs
	Genital infection
	Chronic endomyometritis
	Chronic inflammatory disease of the uterus
	Endometritis
	Endomyometritis
N73.9 Inflammatory diseases of the female pelvic organs, unspecified	Abscess of the pelvic organs
	Bacterial diseases of the urogenital tract
	Bacterial infections of the genitourinary system
	Bacterial infections of the pelvic organs
	Intrapelvic infections
	Inflammation in the area of ​​the cervix
	Pelvic inflammatory disease
	Pelvic inflammatory disease
	Inflammatory gynecological diseases
	Inflammatory diseases of the female pelvic organs
	Inflammatory diseases of the pelvic organs
	Inflammatory diseases of the pelvic organs
	Inflammatory infections in the pelvic area
	Inflammatory processes in the pelvis
	Gynecological infection
	Gynecological infections
	Gynecological infectious diseases
	Purulent-inflammatory diseases of the pelvic organs
	Infections of female genital organs
	Infections of the pelvic organs in women
	Pelvic infections
	Infections of the urogenital tract
	Infectious diseases of the reproductive system
	Infectious diseases of the genital organs
	Infection of female genital organs
	Metritis
	Acute infection of the female genital organs
	Acute inflammatory disease of the pelvic organs
	Pelvic infection
	Tuboovarian inflammation
	Chlamydial gynecological infections
	Chronic inflammatory diseases of the pelvic organs
	Chronic inflammatory diseases of the appendages
	Chronic infections of the female genital organs
N74.2 Inflammatory diseases of the female pelvic organs caused by syphilis (A51.4+, A52.7+)	Syphilis
N74.3 Gonococcal inflammatory diseases of the female pelvic organs (A54.2+)	Gonorrheal diseases
	Gonorrhea
	Gonococcal urethritis